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Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination

Received: 27 June 2022     Accepted: 25 July 2022     Published: 15 August 2022
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Abstract

Corona virus disease (COVID-19) first detected in Wuhan, China in December 2019, spread rapidly to many geographical areas within a few months. As a result, on March 11, 2020 the World Health Organization (WHO) declared COVID-19 as a global pandemic. This disease mainly affected the respiratory system. The review of literature showed a diverse array of clinical features within 2-14 days, that range from asymptomatic and mildly symptomatic to severe illness. However, there is a need to recognize the diversity of clinical features produced by COVID-19 and its variants in Pakistan. The objective of this study is to determine the frequency of various clinical features during the initial stages of COVID-19 infection. This descriptive cross-sectional study was conducted at Fazaia Medical College and PAF hospital Islamabad from April 2020 to March 2022 after approval from the institutional ethical committee. By using WHO sample size calculator, the calculated sample size was 385. The data was collected by using a self-administered questionnaire. Only those patients were included in the study who had a positive RT-PCR for SARS-COVID-19. Data was entered and analyzed by using SPSS version 22.0. Chi.square test was applied. We divided our study into two phases. Out of 385 patients, 218 were included in phase-1 while 167 were included in phase-2. Dominant symptoms of phase 1 were fever (92.7%), anosmia / parosmia (82.1%), taste disturbance (81.2%), sore throat (74.3%) and lethargy (74.3%) but the dominant symptoms of phase 2 were fever (91.6%), sore throat (80.8%), lethargy (78.4%), odynophagia (73.7%) and cough (70.7%). P-value was < 0.001 and was extremely significant for dyspnea, loss of taste and anosmia. This study concludes that the most reliable symptoms for clinical diagnosis and referral for PCR are Fever, Sore throat and Lethargy.

Published in International Journal of Otorhinolaryngology (Volume 8, Issue 2)
DOI 10.11648/j.ijo.20220802.15
Page(s) 52-56
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

COVID-19, Diarrhea, Smell Disorder, Clinical Symptom, Taste Disorder, Meta-analysis

References
[1] Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020; 9 (1): 221-236. [PMC free article] [PubMed].
[2] Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013 Oct; 21 (10): 544-55. [PMC free article] [PubMed].
[3] Guo ZD, Wang ZY, Zhang SF, Li X, Li L, Li C, Cui Y, Fu RB, Dong YZ, Chi XY, Zhang MY, Liu K, Cao C, Liu B, Zhang K, Gao YW, Lu B, Chen W. Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020. Emerg Infect Dis. 2020 Jul; 26 (7): 1583-1591. [PMC free article] [PubMed].
[4] Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, Taylor HS, Tal R. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021 Jan; 224 (1): 35-53.e3. [PMC free article] [PubMed].
[5] Erin K. Stokes, MPH, Laura D. Zambrano, PhD, et al. Coronavirus Disease 2019 Case Surveillance — United States, January 22–May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 19; 69 (24): 759–765.
[6] Murad Habib, MBBS and Muhammad Abbas, PharmD, MClinPharm. Facing the Threat of COVID-19 in Pakistan: A Nation’s Dilemma: Value Health Reg Issues. 2021 May; 24: 90–95.
[7] Gandhi RT, Lynch JB, Del Rio C. Mild or Moderate COVID-19. N Engl J Med. 2020 Oct 29; 383 (18): 1757-1766. [PubMed].
[8] Raseen Tariq, Srishti Saha, Fateeha Furqan, et al. Prevalence and Mortality of COVID-19 Patients With Gastrointestinal Symptoms: A Systematic Review and Meta-analysis.
[9] Environ Microbiol. SARS-CoV-2 variants: Relevance for symptom granularity, epidemiology, immunity (herd, vaccines), virus origin and containment? 2020 May 19: 10.1111/1462-2920.15053.
[10] Marco Cascella; Michael Rajnik; Abdul Aleem; Scott C. Dulebohn; Raffaela Di Napoli. Features, Evaluation, and Treatment of Coronavirus (COVID-19). Treasure Island (FL): StatPearls Publishing; 2022 Jan- Last Update: February 5, 2022.
[11] Nishiura H, Kobayashi T, Miyama T, Suzuki A, Jung SM, Hayashi K, Kinoshita R, Yang Y, Yuan B, Akhmetzhanov AR, Linton NM. Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19). Int J Infect Dis. 2020 May; 94: 154-155. [PMC free article] [PubMed].
[12] Mizumoto K, Kagaya K, Zarebski A, Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Euro Surveill. 2020 Mar; 25 (10) [PMC free article] [PubMed].
[13] Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, Azman AS, Reich NG, Lessler J. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020 May 05; 172 (9): 577-582. [PMC free article] [PubMed].
[14] Ferrando C, Suarez-Sipmann F, Mellado-Artigas R, Hernández M, Gea A, Arruti E, Aldecoa C, Martínez-Pallí G, Martínez-González MA, Slutsky AS, Villar J., COVID-19 Spanish ICU Network. Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive Care Med. 2020 Dec; 46 (12): 2200-2211. [PMC free article] [PubMed].
[15] Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, Liu S, Yang JK. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health. 2020; 8: 152. [PMC free article] [PubMed].
[16] Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C., and Garry, R. F. (2020) The proximal origin of SARS-CoV-2. Nat Med 26: 450–452. [PMC free article] [PubMed] [Google Scholar].
[17] Armengaud, J., Delaunay-Moisan, A., Thuret, J.-Y., van Anken, E., Acosta-Alvear, D., Aragón, T., et al (2020) The importance of naturally attenuated Sars-Cov-2 in the fight against COVID-19. Environ Microbiol. in press, https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.15039. [PMC free article] [PubMed] [Google Scholar].
[18] Lei J, Kusov Y, Hilgenfeld R. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral Res. 2018 Jan; 149: 58-74. [PMC free article] [PubMed].
[19] Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020 Apr; 5 (4): 335-337. [PMC free article] [PubMed].
[20] Patel KP, Patel PA, Vunnam RR, Hewlett AT, Jain R, Jing R, Vunnam SR. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. J Clin Virol. 2020 Jul; 128: 104386. [PMC free article] [PubMed].
[21] Aleem A, Shah H. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Jan 5, 2022. Gastrointestinal And Hepatic Manifestations Of Coronavirus (COVID-19) [PubMed].
[22] Lin L, Jiang X, Zhang Z, Huang S, Zhang Z, Fang Z, Gu Z, Gao L, Shi H, Mai L, Liu Y, Lin X, Lai R, Yan Z, Li X, Shan H. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020 Jun; 69 (6): 997-1001. [PMC free article] [PubMed].
[23] Azouz E, Yang S, Monnier-Cholley L, Arrivé L. Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19. Intensive Care Med. 2020 Jul; 46 (7): 1464-1465. [PMC free article] [PubMed].
[24] Callaway E. Heavily mutated Omicron variant puts scientists on alert. Nature. 2021 Dec; 600 (7887): 21. [PubMed].
[25] Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, Adams G, Hornick JL, Padera RF, Sabeti P. Neuropathological Features of COVID-19. N Engl J Med. 2020 Sep 03; 383 (10): 989-992. [PMC free article] [PubMed].
[26] Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA Neurol. 2020 Aug 01; 77 (8): 1018-1027. [PMC free article] [PubMed].
[27] Abdul Aleem 1, Abdul Bari Akbar Samad 2, Amy K. Slenker 3 In. Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against Coronavirus (COVID-19): StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. 2022 Feb 6.
Cite This Article
  • APA Style

    Tallat Najeeb, Nisa Siddiqui, Abdul Hameed Bhatti. (2022). Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination. International Journal of Otorhinolaryngology, 8(2), 52-56. https://doi.org/10.11648/j.ijo.20220802.15

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    ACS Style

    Tallat Najeeb; Nisa Siddiqui; Abdul Hameed Bhatti. Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination. Int. J. Otorhinolaryngol. 2022, 8(2), 52-56. doi: 10.11648/j.ijo.20220802.15

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    AMA Style

    Tallat Najeeb, Nisa Siddiqui, Abdul Hameed Bhatti. Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination. Int J Otorhinolaryngol. 2022;8(2):52-56. doi: 10.11648/j.ijo.20220802.15

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  • @article{10.11648/j.ijo.20220802.15,
      author = {Tallat Najeeb and Nisa Siddiqui and Abdul Hameed Bhatti},
      title = {Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination},
      journal = {International Journal of Otorhinolaryngology},
      volume = {8},
      number = {2},
      pages = {52-56},
      doi = {10.11648/j.ijo.20220802.15},
      url = {https://doi.org/10.11648/j.ijo.20220802.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijo.20220802.15},
      abstract = {Corona virus disease (COVID-19) first detected in Wuhan, China in December 2019, spread rapidly to many geographical areas within a few months. As a result, on March 11, 2020 the World Health Organization (WHO) declared COVID-19 as a global pandemic. This disease mainly affected the respiratory system. The review of literature showed a diverse array of clinical features within 2-14 days, that range from asymptomatic and mildly symptomatic to severe illness. However, there is a need to recognize the diversity of clinical features produced by COVID-19 and its variants in Pakistan. The objective of this study is to determine the frequency of various clinical features during the initial stages of COVID-19 infection. This descriptive cross-sectional study was conducted at Fazaia Medical College and PAF hospital Islamabad from April 2020 to March 2022 after approval from the institutional ethical committee. By using WHO sample size calculator, the calculated sample size was 385. The data was collected by using a self-administered questionnaire. Only those patients were included in the study who had a positive RT-PCR for SARS-COVID-19. Data was entered and analyzed by using SPSS version 22.0. Chi.square test was applied. We divided our study into two phases. Out of 385 patients, 218 were included in phase-1 while 167 were included in phase-2. Dominant symptoms of phase 1 were fever (92.7%), anosmia / parosmia (82.1%), taste disturbance (81.2%), sore throat (74.3%) and lethargy (74.3%) but the dominant symptoms of phase 2 were fever (91.6%), sore throat (80.8%), lethargy (78.4%), odynophagia (73.7%) and cough (70.7%). P-value was < 0.001 and was extremely significant for dyspnea, loss of taste and anosmia. This study concludes that the most reliable symptoms for clinical diagnosis and referral for PCR are Fever, Sore throat and Lethargy.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Comparison of Early Symptoms of COVID-19 Patients with Different Variants Before and After Vaccination
    AU  - Tallat Najeeb
    AU  - Nisa Siddiqui
    AU  - Abdul Hameed Bhatti
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    T2  - International Journal of Otorhinolaryngology
    JF  - International Journal of Otorhinolaryngology
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    UR  - https://doi.org/10.11648/j.ijo.20220802.15
    AB  - Corona virus disease (COVID-19) first detected in Wuhan, China in December 2019, spread rapidly to many geographical areas within a few months. As a result, on March 11, 2020 the World Health Organization (WHO) declared COVID-19 as a global pandemic. This disease mainly affected the respiratory system. The review of literature showed a diverse array of clinical features within 2-14 days, that range from asymptomatic and mildly symptomatic to severe illness. However, there is a need to recognize the diversity of clinical features produced by COVID-19 and its variants in Pakistan. The objective of this study is to determine the frequency of various clinical features during the initial stages of COVID-19 infection. This descriptive cross-sectional study was conducted at Fazaia Medical College and PAF hospital Islamabad from April 2020 to March 2022 after approval from the institutional ethical committee. By using WHO sample size calculator, the calculated sample size was 385. The data was collected by using a self-administered questionnaire. Only those patients were included in the study who had a positive RT-PCR for SARS-COVID-19. Data was entered and analyzed by using SPSS version 22.0. Chi.square test was applied. We divided our study into two phases. Out of 385 patients, 218 were included in phase-1 while 167 were included in phase-2. Dominant symptoms of phase 1 were fever (92.7%), anosmia / parosmia (82.1%), taste disturbance (81.2%), sore throat (74.3%) and lethargy (74.3%) but the dominant symptoms of phase 2 were fever (91.6%), sore throat (80.8%), lethargy (78.4%), odynophagia (73.7%) and cough (70.7%). P-value was < 0.001 and was extremely significant for dyspnea, loss of taste and anosmia. This study concludes that the most reliable symptoms for clinical diagnosis and referral for PCR are Fever, Sore throat and Lethargy.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Department of ENT, FMC Air University, Islamabad, Pakistan

  • Department of Pathology, FMC Air University, Islamabad, Pakistan

  • Department of Anaesthesia, FMC Air University, Islamabad, Pakistan

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